The Dragon two-handed sword is the fifth strongest two-handed sword available, succeeded by the various types of godsword, and the seventh strongest non-degradable weapon, surpassed by the barrelchest anchor, godswords, and Balmung. It can only be wielded by members who have at least 60 Attack. It is dropped by the Chaos Elemental and the Kalphite Queen, and can also be looted from a kingly impling jar.

The dragon two-handed sword has a special attack, Powerstab, which can hit all enemies in the squares around the player, but only in a multicombat area. This makes the special attack effective in combat situations with multiple opponents. However, it uses 60% of a player's special attack energy, so it cannot be done in rapid succession. Players typically prefer to buy an Abyssal whip or Saradomin sword rather than the Dragon two-handed sword. Against players, the weapon's maximum hit is 580 (if using PvP armour and all the best secondary equipment, potions, prayers, etc.), or 490 with Void equipment and the other aforementioned items (not yet confirmed).

With the release of Item Lending, the dragon two-handed sword, like the godsword, is in somewhat popular demand for inexperienced players wishing to see their maximum hit and/or deciding if it is something they wish to buy. This weapon is mostly seen borrowed/lent near the Pest Control landers.

However, the dragon two-handed sword is one of the few dragon weapons that do not require the completion of a quest. Because of this and its large strength/slash bonus, it is popular for training in dense areas.

In early May 2009, the price of the dragon two-handed sword crashed. It fell from around one million coins to around 600,000 coins. After a slight price recovery around 19 May 2009, the sword continued to fall in price and, in the crash, people were frantically selling them in junk trades. The price has since made a significant recovery.

The Dragon 2H special attack may be useful when fighting Dagannoths under the light house because it's a multi-combat area.